What is the pathophysiological basis for narcolepsy or hypersomnolence?

Monday, May 25th, 2009

I’m trying to understand these conditions beyond textbook exerpt and internet sites describing narcolepsy in scant detail. Please help provide some more details if you can. I am highly interested in these disorders and what exactly causes them. Also, what is the best treatment?

Narcolepsy is thought to result from genetic predisposition, abnormal neurotransmitter functioning and sensitivity, and abnormal immune modulation. Current data implicate certain human leukocyte antigen (HLA) subtypes and abnormalities in monoamine synaptic transmission, particularly in the pontine reticular activating system.

Sleep Apnea

Wednesday, May 6th, 2009

Sleep Apnea
Considers the relationship between obstructive sleep apnea (OSA) and cardiovascular disease, right and left ventricular dysfunction, and hypertension. Sleep Apnea analyzes -techniques to identify, diagnose, and monitor sleep-induced upper airway obstruction -developments in functional brain imaging associated with sleep and sleep deprivation -advances in oral appliance and continuous positive airway pressure (CPAP) therapies and explores -breakthroughs in the establishment of genetic, environmental, and developmental factors of OSA -the significance of cytokines in sleep regulation -the effect of sleep on ventilatory control Summarizing landmark studies in the field and providing more than 2000 contemporary references to facilitate further scientific investigation, Sleep Apnea is an in-depth guide for pulmonologists; physiologists; chest, pulmonary, thoracic, and cardiovascular physicians and surgeons; cardiologists; respiratory therapists; clinical neurologists; sleep disorder specialists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

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